|
|
Voltammetric Determination of Warfarin at a Screen-Printed Carbon Electrode
Žužičová, Victória ; Vyskočil, Vlastimil (advisor) ; Dejmková, Hana (referee)
In this Bachelor Thesis, the electrochemical behaviour of the drug warfarin sodium was studied at a screen-printed carbon electrode (SPCE) using DC voltammetry (DCV) and differential pulse voltammetry (DPV). The dependence of the voltammetric behaviour of the substance on the pH of the medium was studied in Britton-Robinson buffer (BR buffer) in the pH range of 2.0−12.0. A pH of 7.0 was chosen as the optimum pH for both voltammetric techniques. A repeatability of 3.8% for DCV and 4.3% for DPV was determined for the selected pH. Calibration dependence was monitored under the selected optimal conditions in the concentration range 2∙10−6 to 1∙10−4 mol∙dm−3 . The limit of detection (LOD) was determined to be 1.05∙10−6 mol∙dm−3 for DCV and 2.59∙10−7 mol∙dm−3 for DPV. The limit of quantification (LOQ) was 3.50∙10−6 mol∙dm−3 for DCV and 8.62∙10−7 mol∙dm−3 for DPV. These newly developed methods were used for the determination of the active ingredient in the pharmaceutical formulation Warfarin Orion 5 mg. The values measured by voltammetric methods were compared with those obtained by spectrophotometric measurements. Key words Electrochemistry, Warfarin, Anticoagulants, Direct Current Voltammetry, Differential Pulse Voltammetry, Screen-Printed Carbon Electrode
|
|
|
Compliance with mode measures by the anticoagulative treatment in primary medical care
PROCHÁZKOVÁ, Alexandra
The goal of my bachelor´s thesis has been a description of state compliance with patients taking Warfarin and afterwards the relationship between measurement of compliance and occurrence of complications related to the treatment with Warfarin. Concurrently, compliance from the point of age and gender has been meant to be supported. The theoretical part has been dedicated to anticoagulative treatment with emphasis on Warfarin, education and patient´s compliance by observance of mode measures related to treatment with Warfarin. Quantitative research survey has been chosen to process this bachelor´s thesis with using of technique of data collecting with a form of an anonymous unstandardized questionnaire survey. The survey team has consisted of the patients in České Budějovice taking Warfarin. Three hypotheses have been specified in connection with the goal of this thesis. We have assumed by the two mentioned hypotheses such a kind of relation between the state compliance connected to their age, then between mode compliance and their gender. By the third hypothesis we have claimed that occurrence that could have been related to the mode compliance. Thanks to the given results we have found out that there is no relation to their age or gender by the patients taking Warfarin, but there is a relation to the patients taking Warfarin and mode compliance. Beyond the given goal we have come to the conclusion that compliance is related to the achieved education and also it decreases with its length. The results could be used as a material for nurses´ education in surgeries or for general practitioners in some other hospitals. There has been pointed out the necessity of a proper education, patients awareness and importance of mutual relations and communication. These facts could influence the patient´s contribution to mode treatment and increase its success rate. This work provides complete information regarding treatment with Warfarin and also possible consequences by using wrong patient´s compliance.
|
|
|
Novel anticoagulants from the perspective of cardiac patients
KŘÍŽOVÁ, Anna
The bachelor thesis deals with anticoagulant treatment in cardiac patients and their satisfaction with it. Over time, anticoagulant therapy is becoming one of the most widespread areas, which is represented in almost every field of contemporary medicine and nursing. In cardiac patients, anticoagulant treatment plays a very important and irreplaceable role in the prevention and treatment of the disease itself. The aim of this bachelor thesis is to map the awareness, advantages and disadvantages of anticoagulant treatment with warfarin or one of the representatives of NOAK according to the experience of patients with atrial fibrillation and then compare the resulting parameters. A qualitative survey method was chosen for the research survey. Data were obtained through semi-structured interviews with patients. A total of 16 patients were contacted, 8 of whom were taking warfarin and the remaining 8 patients were taking NOAK - 4 Xarelto patients, 3 Pradax patients and 1 Eliquis patient. The results of the research showed that patients are insufficiently informed about their options in the selection of anticoagulants. Another shortcoming in the education of patients about anticoagulant treatment is the insufficient use of an information brochure. The results also showed that patients on NOAK are more satisfied with anticoagulant therapy than on warfarin, as it does not bring them so many limitations. However, side effects were more common in patients with NOAK than with warfarin. Overall, however, both groups of patients evaluate anticoagulant therapy rather positively. Based on the results, an informative brochure for patients with anticoagulant treatment was created as part of the work, which can help them decide between anticoagulant drugs and get acquainted with their options.
|
|
| |
|
|
Linking of diet with warfarin in senior age
NOVÁKOVÁ, Tereza
Any diet during the warfarin treatment is a highly discussed topic. The bachelor thesis focuses on the relations between a nutrition and warfarin among elderly population. The thesis itself is divided into a theoretical and a practical part. The theoretical part describes anticoagulation therapy, warfarin, new oral anticoagulation, K vitamin, relations between nutrition and warfarin and seniors. The practical part inquires the general awareness among the seniors of the potential relations between warfarin and anticoagulation therapy and their eating habits. The methodology of qualitative research (semi-structured interviews) was used for gathering the information in the practical part of the thesis. The interviews were realized in a hospital (8 seniors) and also in the houses of the respondents (2 seniors). The thesis also provides the assessment of 5 daily menus of 10 interviewed seniors through the Nutriservis program, the USDA database and the literature (Kohout et al., 2007). As the outputs of the program, the database and the literature all the detected values were compared with estimated vitamin K values among the above 65 years population stated in the "Referenční hodnoty pro příjem ţivin, 2011" publication. The issue of relations between nutrition and the warfarin treatment is accepted basically well. The outputs clearly show that the mistake seniors often do is a vegetable elimination from the menu due to the concerns of a warfarin treatment disorder. The seniors also believe that they shall not consume any green vegetable at all. Concerning the outputs of the thesis it is necessary to focus more on providing correct information to the patients about the importance of including the vegetable in their menu and proposing the appropriate and inappropriate foods. Therefore the professional advice of the nutrition therapist is crucial to discuss deeply the relation between a nutrition and warfarin with the patients. The thesis might be an information source for the seniors using warfarin.
|
|
|
Problems of anticoagulation therapy in terms of nurses and patients
KLÍMOVÁ, Adéla
This bachelor thesis deals with the use of oral anticoagulant drugs. It focuses primarily on issues of use in terms of patients and nurses. The aim of the work was to find patients' issues in taking oral anticoagulants and the ex-perience of nurses with complications of anticoagulation therapy. To achieve this goal, the empirical section was elaborated through a qualitative research survey conducted through semi-structured interviews with patients using anticoagulant medications and nurses working in outpatient or inpatient cardiology departments. Many surprising results were achieved by the research. The results demonstrated that nurses need to educate themselves about introducing new drugs. Further, nurses are not a primary source of information for the patient. They usually receive questions from pa-tients not explained to the doctor or necessary to repeat to patients. It has been found that nurses often do not encounter complications and have experienced more serious compli-cations only exceptionally. From interviews with patients, it was found that the most common complication they encountered was bleeding from Warfarin. The respondents did not notice any major problems for new oral anticoagulants. In addition, the patients are all informed in the course of the treatment, and each individual receives a variety of informa-tion. The research also demonstrates that patients are also interested in their treatment in-dividually, searching for information on the internet or sharing their experiences with each other. The research was further supplemented by a visit to a special coagulation clinic where the interview was conducted not only with the nurse but with the doctor. The bene-fit the clinic has for patients was presented. Clear material arose thanks to this bachelor thesis, where not only medical staff learned the biggest problems in taking oral anticoagulation therapy.
|
|
|
Nursing care of the patient with ischemic heart disease
Šedová, Lenka ; Heřmanová, Jana (advisor) ; Jirásek, Vít (referee)
Autor práce: Lenka Šedová Vedoucí práce: Mgr. Jana Heřmanová Odborný konzultant: MUDr. Vít Jirásek Téma práce: A Nursing Care of the Patient with Diagnosis Coronary Artery Disease after Surgery Abstract: The aim of the work is to report on the case of a 79-year-old patient after cardiac surgical intervention. The surgery was indicated for coronary artery disease. The clinical part deals with the characteristics and stages of ACD. It also deals with the diagnosis and treatments of UP (unstable angina). The next part describes the patient's hospitalization. The last part describes the palliative care of this patient, his psychological rehabilitation and his return to daily life. The nursing history is formulated according to the theory of Virginie Henderson. An important role in the reduction of complications is the education of patient. Key words: ACD, UA, nursing proces, Henderson's theory, aortocoronary bypass, Warfarin, methods of invstigation, self-sufficiency, self-care
|
|
| |
|
|
Anticoagulant therapy focusing on patients with atrial fibrillation
VANÍČKOVÁ, Martina
Thrombosis has recently become a widely discussed issue due to an increasing number of cases and problematic treatment. Once developed, thrombosis cannot be cured completely. Currently used anticoagulant treatment is limited to avoid complications such a hemorrhage or stroke. INR value checks (Quick tests) and monitoring covering at least 70% of the treatment period within the therapeutic range are necessary (2-3), but could be rather difficult to maintain in some patients. So-called new anticoagulants could prove themselves as an appropriate solution.
|
|
| |
guest ::
